Colloidal Silver Research

• Study indicates nano-Ag (colloidal silver) may have considerable antifungal activity
• Nano-Ag (colloidal silver) has considerable antifungal activity...
• Silver nanoparticles inhibit the (HIV-1) virus from binding to host cells...
• This is the first comparative study on the bactericidal properties of silver nanoparticles
• Comparison of the antibacterial activities of the silver- supported materials prepared by silver colloid deposition and by conventional thermal impregnation technique indicates that former is more efficient in controlling microorganism.

Antifungal effect of silver nanoparticles on dermatophytes. Kim KJ, Sung WS, Moon SK, Choi JS, Kim JG, Lee DG.

Department of Microbiology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea.

Spherical silver nanoparticles (nano-Ag) were synthesized and their antifungal effects on fungal pathogens of the skin were investigated. Nano-Ag showed potent activity against clinical isolates and ATCC strains of Trichophyton mentagrophytes and Candida species (IC80, 1-7 microg/ml). The activity of nano-Ag was comparable to that of amphotericin B, but superior to that of fluconazole (amphotericin B IC80, 1-5 microg/ml; fluconazole IC80, 10- 30 microg/ml). Additionally, we investigated their effects on the dimorphism of Candida albicans. The results showed nano-Ag exerted activity on the mycelia. Thus, the present study indicates nano-Ag may have considerable antifungal activity, deserving further investigation for clinical applications.

Antifungal activity and mode of action of silver nano-particles on Candida albicans.Kim KJ, Sung WS, Suh BK, Moon SK, Choi JS, Kim JG, Lee DG.

Department of Microbiology, College of Natural Sciences, Kyungpook National University, 1370 Sankyuk-dong, Puk-ku, Daegu, 702-701, South Korea.

In this study, the antifungal effects of silver nano-particles (nano-Ag) and their mode of action were investigated. Nano-Ag showed antifungal effects on fungi tested with low hemolytic effects against human erythrocytes. To elucidate the antifungal mode of action of nano-Ag, flow cytometry analysis, a glucose-release test, transmission electron microscopy (TEM) and the change in membrane dynamics using 1,6-diphenyl-1,3,5-hexatriene (DPH), as a plasma membrane probe, were performed with Candida albicans. The results suggest nano-Ag may exert an antifungal activity by disrupting the structure of the cell membrane and inhibiting the normal budding process due to the destruction of the membrane integrity. The present study indicates nano-Ag has considerable antifungal activity, deserving further investigation for clinical applications.

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